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Erratum

    Science (New York, N.Y.)
    |November 13, 1981
    PubMed

    Insights

    A correction to a previous report clarifies the labeling of Figure 1B. This figure illustrates the selective protection of methionine enkephalin in brain slices through enkephalinase inhibition.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Pharmacology

    Background:

    • Methionine enkephalin is a key endogenous opioid peptide.
    • Enkephalinase enzymes degrade methionine enkephalin.
    • Understanding opioid peptide regulation is crucial for pain research.

    Purpose of the Study:

    • To correct an error in Figure 1B of a previous publication.
    • To accurately present data on methionine enkephalin protection.
    • To ensure clarity in the study of enkephalinase inhibition.

    Main Methods:

    • In vitro studies using brain slices.
    • Measurement of methionine enkephalin levels.
    • Application of enkephalinase inhibitors.

    Main Results:

    • The corrected Figure 1B accurately depicts the selective protection of methionine enkephalin.
    • Enkephalinase inhibition effectively prevents the degradation of released methionine enkephalin.
    • Data supports the role of enkephalinase in modulating endogenous opioid signaling.

    Conclusions:

    • Accurate data presentation is vital for scientific reproducibility.
    • Enkephalinase inhibitors offer a strategy for enhancing endogenous opioid activity.
    • This finding has implications for developing novel analgesics.

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