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Chemical sensing in process analysis.

T Hirschfeld, J B Callis, B R Kowalski

    Science (New York, N.Y.)
    |October 19, 1984
    PubMed
    Summary
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    Advanced sensor technology and chemometrics will enhance on-line process analysis for improved production efficiency and quality. Future instrumentation will feature miniaturized, self-calibrating sensors for real-time data and better error detection.

    Area of Science:

    • Process Analytical Technology (PAT)
    • Chemical Instrumentation
    • Materials Science

    Background:

    • On-line process analysis is crucial for optimizing production efficiency and product quality.
    • Current instrumentation technology requires significant advancement to meet future demands.

    Purpose of the Study:

    • To outline the future technological advancements in sensing devices for on-line process analysis.
    • To highlight the role of chemometrics in enhancing process control software.

    Main Methods:

    • Development of sensor arrays and miniaturized instruments using microlithography and silicon micromachining.
    • Extensive application of chemometrics for error detection, self-calibration, correction, and multivariate data analysis.
    • Adoption of new paradigms and tools for fabricating monolithic sensors.

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    Main Results:

    • Emergence of advanced sensor arrays and miniaturized instruments.
    • Integration of sophisticated chemometrics software for robust data analysis and error management.
    • Demonstration of monolithically fabricated sensors with potential for wider adoption.

    Conclusions:

    • Future process control relies on advanced on-line analysis driven by novel sensing technologies.
    • Miniaturized, self-calibrating sensors and chemometrics will revolutionize process monitoring.
    • A discernible trend towards in-product sensing indicates a move beyond traditional on-line analysis.