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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
Heterozygous Beta thalassemia: balanced globin synthesis in bone marrow cells
Science (New York, N.Y.)
|March 13, 1970
Abstract:
In two patients with heterozygous beta thalassemia the rates of synthesis of the alpha and beta chains of hemoglobin were equal in nucleated red cell precursors, although beta chain synthesis was reduced in peripheral blood reticulocytes. This finding suggests a relative instability of beta chain messenger RNA in beta thalassemia.
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
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