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Updated: Jul 12, 2026

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Published on: February 27, 2014
BIOTIN DEFICIENCY AND OTHER CHANGES IN RATS GIVEN SULFANILYLGUANIDINE OR SUCCINYL SULFATHIAZOLE IN PURIFIED DIETS
Abstract:
The following pathological changes have been observed in rats given sulfaguanidine or sulfasuxidine in purified diets. 1. A granulocytopenia, leukopenia, hypocellularity of bone marrow and, occasionally, an anemia. 2. Hyalinization, necrosis and calcification of voluntary muscle. 3. Hyaline sclerosis and calcification of blood vessels. 4. A dermatitis which can be prevented or successfully treated with crystalline biotin. We have also observed necrosis of heart muscle, hemorrhage into various organs and subcutaneous tissues, and liver damage.
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