Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dialysis membranes decrease immunoglobulin and interleukin-6 production by peripheral blood mononuclear cells in

L Paczek1, R M Schaefer, A Heidland

  • 1Department of Internal Medicine, University of Würzburg, Germany.

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Is vitamin D deficiency related to accumulation of advanced glycation end products, markers of inflammation, and oxidative stress in diabetic subjects?

BioMed research international·2015
Same author

The role of emeriti and retired professors in medicine.

QJM : monthly journal of the Association of Physicians·2014
Same author

Aldosterone causes DNA strand breaks and chromosomal damage in renal cells, which are prevented by mineralocorticoid receptor antagonists.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2010
Same author

Alterations in Cyclic AMP Concentration and Adenylate Cyclase Activity in Specific Brain Areas of Rats with Inherited Hypothalamic Diabetes Insipidus (Brattleboro Rats).

Journal of neuroendocrinology·2009
Same author

Neuronal activation in the CNS during different forms of acute renal failure in rats.

Neuroscience·2009
Same author

[Effects of proteolytic enzymes on advanced glycation end-products (AGEs): possible clinical implications].

Deutsche medizinische Wochenschrift (1946)·2008
Same journal

Correction to: Hyponatraemia-treatment standard 2024.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Effect of Semaglutide on Measured vs Estimated Glomerular Filtration Rate.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Beyond Diffusion and Convection: Is Adsorption the Third Dimension of Dialysis?

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Pivotal Clinical Trials in C3 Glomerulopathy: answers and remaining uncertainties.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Urinary protein vs albumin for assessing kidney failure risk in chronic kidney disease.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
Same journal

Systolic blood pressure and albuminuria reduction mediate cardiovascular benefits of finerenone in T2 diabetes and CKD.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2026
See all related articles

Dialysis membranes significantly reduce immunoglobulin (Ig) and interleukin-6 (IL-6) production by immune cells. This suggests that membrane material impacts immune responses during hemodialysis.

Area of Science:

  • Immunology
  • Nephrology
  • Biomaterials Science

Background:

  • Hemodialysis patients often experience altered immune function.
  • Dialysis membranes are crucial for waste removal but can interact with blood components.

Purpose of the Study:

  • To investigate the impact of different dialysis membrane materials on immunoglobulin and interleukin-6 production.
  • To understand how Cuprophan, Hemophan, and polyacrylonitrile affect immune cell function.

Main Methods:

  • Peripheral blood mononuclear cells (PBMC) from 11 hemodialysis patients were cultured for 7 days on various dialysis membranes (Cuprophan, Hemophan, polyacrylonitrile) and polystyrole.
  • Interleukin-6 (IL-6), IgG, IgA, and IgM levels in culture supernatants were measured using ELISA.

Related Experiment Videos

Main Results:

  • Pokeweed-mitogen-stimulated IgG and IgA production by PBMC significantly decreased on Cuprophan, Hemophan, and polyacrylonitrile compared to polystyrole.
  • IL-6 production by PBMC was also significantly reduced in the presence of these dialysis membranes compared to polystyrole.

Conclusions:

  • Dialysis membrane materials influence immunoglobulin and IL-6 production.
  • Reduced IL-6 levels suggest diminished monocyte stimulation, potentially leading to decreased B cell activity in hemodialysis patients.