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Updated: Jul 12, 2026
![Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F60445.jpg&w=3840&q=50)
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate (DMBA-TPA)
Published on: December 19, 2019
THE ROLE OF CALCIUM IN CARCINOGENESIS SUMMARY
Abstract:
Estimations of the calcium content of the mouse epidermis during the process of experimental carcinogenesis reveal two distinct phases: an immediate reduction in the calcium content which persists at a fairly constant level for many weeks and a further reduction when the epithelial cells have been transformed into cancer cells. Reduction of calcium in the hyperplastic epidermis is an important feature in this experimentally induced precancerous condition. This investigation was aided by grants from the International Cancer Research Foundation and the National Cancer Institute.
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