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Baclofen-induced frontal lobe syndrome: case report
1Neurological Center, Veterans General Hospital-Taipei, Taiwan, Republic of China.
Paraplegia
|October 1, 1991
Summary
Baclofen, a medication for spasticity, can cause acute frontal lobe syndrome in elderly patients. Symptoms resolved within 72 hours after discontinuing baclofen (70 mg).
Area of Science:
- Neurology
- Pharmacology
Background:
- Cervical spondylotic myelopathy is a condition causing spinal cord compression in the neck.
- Spasticity is a common symptom requiring management, often with muscle relaxants like baclofen.
Observation:
- An 81-year-old male patient with cervical spondylotic myelopathy presented with an acute frontal lobe-like syndrome.
- The patient had received seven doses (70 mg) of baclofen for spasticity prior to symptom onset.
Findings:
- The patient exhibited an abnormal electroencephalogram (EEG) alongside the neurological syndrome.
- Clinical symptoms, including the frontal lobe-like syndrome and EEG abnormalities, resolved within 72 hours of baclofen discontinuation.
Implications:
- This case highlights a potential adverse effect of baclofen in the elderly population.
- Clinicians should consider baclofen-induced neurotoxicity when evaluating acute neurological changes in patients on this medication.