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Updated: Jul 12, 2026

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Discovery of New Intracellular Pathogens by Amoebal Coculture and Amoebal Enrichment Approaches
Published on: October 27, 2013
Temperature sensitivity: a cell character determined by obligate endosymbionts in amoebas
Abstract:
A strain of Amoeba proteus has lost its ability to survive at temperatures above 26 degrees C as a result of becoming dependent on endosymbiotic bacteria that are psychrophile-like. The observed temperature sensitivity develops in fewer than 200 host cell generations (18 months of culture) after the host cells are experimentally infected with the symbionts.
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