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Pulmonary fibrosis associated with nabumetone
A Morice1, A Atherton, F Gleeson
1Chest Medical Unit, Papworth Hospital, Cambs, UK.
Postgraduate Medical Journal
|November 1, 1991
Summary
Nabumetone, a non-steroidal anti-inflammatory drug, caused rapid pulmonary fibrosis in a patient. Symptoms resolved after discontinuing nabumetone and initiating steroid therapy.
Area of Science:
- Pulmonology
- Pharmacology
- Toxicology
Background:
- Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
- Drug-induced lung injury is a recognized but uncommon adverse effect of medications.
Observation:
- A patient presented with acute onset of pulmonary fibrosis.
- The condition rapidly developed after the initiation of nabumetone therapy.
Findings:
- Pulmonary fibrosis symptoms, physical signs, and radiographic evidence resolved upon cessation of nabumetone.
- The patient's condition improved with the addition of corticosteroid treatment.
Implications:
- This case highlights a potential severe adverse reaction to nabumetone, specifically pulmonary fibrosis.
- Clinicians should consider nabumetone as a potential cause of drug-induced pulmonary fibrosis in patients presenting with relevant symptoms.
- Early drug withdrawal and appropriate medical management, including steroids, may lead to favorable outcomes.