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Clinical factors that may confound the assessment of drug efficacy
J G Csernansky1, J W Newcomer, L S Miller
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Psychopharmacology Bulletin
|January 1, 1991
Abstract:
The development of new chemical classes of psychotherapeutic drugs offers the potential for new patterns of drug efficacy as well as decreases in side effects. However, the determination of drug efficacy can be confounded by sample selection and outcome determination factors. The ability of selected clinical factors of both types to affect the outcome of antipsychotic drug trials is reviewed. Suggestions for future clinical drug trials are made.