Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cushing Syndrome II: Pathophysiology

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...

Hypothalamic-Pituitary Axis

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.

Cushing Syndrome I: Introduction

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Paraoxonase-1 activity and AOPP levels in patients with type 2 diabetes mellitus.

Journal of medical biochemistry·2026

Same author

Structures at Risk With Intrapelvic Guide Wire Migration During Cephalomedullary Fixation of Hip Fractures: CT-Based Analysis.

Journal of orthopaedic trauma·2025

Same author

Evaluation of cognitive dysfunction by the clock drawing test in multiple sclerosis and clinically isolated syndrome patients: Correlation with other neuropsychological tests.

Neurosciences (Riyadh, Saudi Arabia)·2022

Same author

Evaluation of the Design and Methodology of Applications to the Local Ethics Committee.

Sisli Etfal Hastanesi tip bulteni·2022

Same author

Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer's disease.

Aging medicine (Milton (N.S.W))·2021

Same author

Altered Expression of Long Non-coding RNAs in Peripheral Blood Mononuclear Cells of Patients with Alzheimer's Disease.

Molecular neurobiology·2020

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Plasma cortisol levels in migraineurs between attacks.

Cağatay Oncel¹, Buket Oflazoğlu, Hulki Forta

¹Department of Neurology, Pamukkale University, Denizli, Turkey. cagatay_oncel@yahoo.com

Agri : Agri (Algoloji) Dernegi'Nin Yayin Organidir = the Journal of the Turkish Society of Algology

|September 1, 2007

Summary

This study found no significant difference in plasma cortisol levels between migraine patients and healthy individuals between attacks. The hypothalamic-pituitary-adrenal axis does not appear to play a role in migraine pathophysiology based on these cortisol measurements.

More Related Videos

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

Related Experiment Videos

Last Updated: Jul 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Detection and Quantification of Calcitonin Gene-Related Peptide (CGRP) in Human Plasma Using a Modified Enzyme-Linked Immunosorbent Assay

Published on: June 16, 2023

Area of Science:

Endocrinology
Neurology
Migraine Research

Background:

The hypothalamic-pituitary-adrenal (HPA) axis is a key regulator of the stress response.
Dysregulation of the HPA axis has been implicated in various neurological and psychiatric conditions.
The specific role of the HPA axis in migraine pathophysiology remains unclear.

Purpose of the Study:

To investigate the potential involvement of the hypothalamic-pituitary-adrenal axis in migraine.
To compare plasma cortisol levels in migraine patients and healthy controls during the interictal period.

Main Methods:

Blood samples were collected from 25 migraine patients and 24 healthy controls.
Plasma cortisol levels were measured between 8:30 AM and 9:30 AM.
Statistical analysis was performed to compare cortisol levels between the two groups.

Main Results:

No statistically significant difference was observed in plasma cortisol levels between migraine patients and the control group.
Cortisol levels in the interictal period did not show a significant association with migraine.

Conclusions:

The findings suggest that the hypothalamic-pituitary-adrenal axis, as assessed by plasma cortisol levels between attacks, does not play a significant role in migraine.
Further research may be needed to explore other aspects of HPA axis function or different time points in relation to migraine.