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Related Experiment Videos

Does the Bravo pH capsule affect esophageal motor function?

J E Pandolfino1, Q Zhang, S K Ghosh

  • 1Department of Medicine, Northwestern University, The Feinberg School of Medicine, Chicago, Illinois 60611, USA. j-pandolfino@northwestern.edu

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
|September 1, 2007
PubMed
Summary
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The Bravo pH monitoring capsule did not significantly alter overall esophageal motility or esophagogastric junction function. However, capsule placement caused a localized increase in peristalsis, particularly in subjects aware of the device.

Area of Science:

  • Gastroenterology
  • Esophageal Physiology
  • Medical Device Technology

Background:

  • The Bravo pH monitoring capsule is a wireless device used for diagnosing gastroesophageal reflux disease.
  • Understanding its impact on esophageal function is crucial for accurate interpretation of motility studies.
  • High-resolution manometry provides detailed assessment of esophageal peristalsis and pressures.

Purpose of the Study:

  • To investigate whether the Bravo pH monitoring capsule affects esophageal motility.
  • To assess changes in esophagogastric junction (EGJ) pressure, relaxation, and peristaltic function post-capsule placement.
  • To correlate subjective awareness of the capsule with objective manometric findings.

Main Methods:

  • Thirty-six channel high-resolution manometry was performed on 20 healthy subjects before and after Bravo capsule placement.

Related Experiment Videos

  • Water and barium swallows were analyzed in upright and supine positions, synchronized with manometry and fluoroscopy.
  • Esophagogastric junction (EGJ) pressure, relaxation, and peristaltic wave characteristics were compared pre- and post-procedure.

    • Main Results:

    • No significant changes were observed in basal EGJ pressure, EGJ relaxation pressure, or overall peristaltic function.
    • A localized 2-cm segment of augmented peristalsis was identified at the capsule's location.
    • Subjects aware of the capsule demonstrated significantly greater peristaltic augmentation compared to unaware subjects (P < 0.05).

    Conclusions:

    • The Bravo pH capsule does not broadly impair esophageal motility or EGJ function.
    • Capsule presence induces a localized peristaltic augmentation, more pronounced in symptomatic individuals.
    • While generally well-tolerated, awareness of the capsule correlates with a specific manometric response.