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Solid intraocular xanthogranuloma in three Miniature Schnauzer dogs
Mitzi K Zarfoss1, Richard R Dubielzig
1Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Veterinary Ophthalmology
|September 1, 2007
Summary
Diabetic Miniature Schnauzers with hyperlipidemia can develop solid intraocular xanthogranulomas. This condition, characterized by foam cells and crystals, can lead to glaucoma and necessitate globe enucleation.
Area of Science:
- Veterinary Pathology
- Ophthalmology
- Canine Disease
Background:
- Foam cells, macrophages laden with intracytoplasmic lipids, can accumulate within ocular tissues.
- Solid intraocular masses composed of foam cells were identified in four canine globes.
Observation:
- Histopathologic review of canine globes revealed solid intraocular masses effacing normal structures.
- These masses consisted of lipid-laden foam cell macrophages and birefringent, Alcian blue-positive crystals in stellate patterns.
Findings:
- All affected globes belonged to Miniature Schnauzers with a history of diabetes mellitus, hyperlipidemia, and lens-induced uveitis.
- Glaucoma was the primary reason for enucleation in all cases.
Implications:
- The term solid intraocular xanthogranuloma is proposed for these specific histopathologic findings.
- Diabetic hyperlipidemic Miniature Schnauzers are identified as a risk group for developing severe, lipid-rich uveitis that can progress to intraocular masses, glaucoma, and enucleation.
