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Updated: Jul 12, 2026

Mitigation of Blood Borne Cell Attachment to Metal Implants through CD47-Derived Peptide Immobilization
Published on: December 3, 2020
Dysregulation of CD47 and the ligands thrombospondin 1 and 2 in multiple myeloma
Jannie M Rendtlew Danielsen1, Lene Meldgaard Knudsen, Inger Marie Dahl
1Department of Haematology 54P4, Herlev University Hospital, University of Copenhagen, Denmark. jrd@cancer.dk
Abstract:
CD47 and thrombospondin 1 and 2 (TSP1 and TSP2) expression were analysed by real-time reverse transcription polymerase chain reaction in fluorescence-activated cell sorted plasma cells (PCs) from patients at consecutive stages of multiple myeloma (MM) development. 80% of MM patients, but only 39% of patients with monoclonal gammopathy of undetermined significance (MGUS) expressed CD47; median expression level increased 10-fold with progression from MGUS to MM. Elevated TSP1/TSP2 levels occurred in bone marrow cultures from MM patients compared with healthy donors. CD47 and TSP1/TSP2 may have a potential role in the pathophysiology of MM, probably in the interaction between MM PCs and the microenvironment.
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