Photosensitisation induced by clofazimine in a cat

Area of Science:

• Veterinary Dermatology
• Feline Medicine
• Pharmacology

Background:

• Feline leprosy, a rare mycobacterial infection, requires antimicrobial treatment.
• Clofazimine is an antibiotic used in treating certain mycobacterial infections.

Observation:

• A pale ginger cat diagnosed with feline leprosy was treated with clofazimine.
• The cat developed a dermatological condition consistent with actinic dermatitis during treatment.
• This condition was identified as photosensitisation induced by clofazimine.

Findings:

• The feline leprosy was successfully treated and cured with clofazimine.
• The photosensitisation adverse effect was managed by controlling the cat's exposure to sunlight.
• This case represents the first documented instance of clofazimine-induced photosensitisation in a feline patient.

Implications:

• Highlights the potential for clofazimine to cause photosensitisation in cats.
• Emphasizes the importance of monitoring for dermatological side effects during clofazimine therapy.
• Informs veterinary practitioners about managing drug-induced photosensitisation in cats with feline leprosy.