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CONDOR: a database resource of developmentally associated conserved non-coding elements.

Adam Woolfe1, Debbie K Goode, Julie Cooke

  • 1School of Biological Sciences, Queen Mary, University of London, Mile End Road, London E1 4NS, UK. woolfea@mail.nih.gov

BMC Developmental Biology
|September 1, 2007
PubMed
Summary
This summary is machine-generated.

This study introduces CONDOR, a database of conserved non-coding elements (CNEs) for studying vertebrate gene regulation. It offers tools to analyze these elements, aiding research into early development and evolution.

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Area of Science:

  • Genomics
  • Evolutionary Biology
  • Developmental Biology

Background:

  • Comparative genomics is crucial for understanding vertebrate genome regulation.
  • Fish-mammal comparisons identify conserved non-coding elements (CNEs) regulating early development.
  • Limited user-friendly resources exist for analyzing these regulatory elements.

Purpose of the Study:

  • To present CONDOR, a database of conserved non-coding elements (CNEs).
  • To provide tools for analyzing CNEs associated with early developmental genes.
  • To facilitate research on the function and evolution of cis-regulatory elements.

Main Methods:

  • Developed CONDOR (COnserved Non-coDing Orthologous Regions) database.
  • Integrated >6800 CNEs linked to >120 early developmental genes.
  • Included data from duplication events and in vivo zebrafish enhancer assays.

Main Results:

  • CONDOR offers an interactive interface for accessing CNE data.
  • The database contains over 6800 conserved non-coding elements.
  • It highlights elements from vertebrate and teleost-specific duplications.

Conclusions:

  • CONDOR provides a valuable resource for studying gene regulation and evolution.
  • The database's accessible interface supports further research.
  • It aids in understanding the function and evolution of developmental cis-regulation.