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Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...

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Related Experiment Video

Updated: Jul 12, 2026

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

Published on: September 20, 2018

Measuring perinatal complications: methodologic issues related to gestational age.

Aaron B Caughey¹

¹University of California, San Francisco, California, USA. abcmd@berkeley.edu

BMC Pregnancy and Childbirth

|September 1, 2007

Summary

Accurate reporting of perinatal complications is crucial. Using the correct denominator, like ongoing pregnancies (OP) for antepartum stillbirths, ensures reliable data for clinicians and policymakers.

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Last Updated: Jul 12, 2026

Anogenital Distance and Perineal Measurements of the Pelvic Organ Prolapse (POP) Quantification System

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Published on: September 20, 2018

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

Obstetrics and Gynecology
Perinatal Epidemiology
Maternal-Fetal Medicine

Background:

Perinatal outcomes vary significantly by gestational age.
Existing studies inconsistently report perinatal complications, using diverse denominators, numerators, and comparison groups.
This variability can obscure true outcome rates and trends.

Discussion:

The choice of denominator critically impacts the reported incidence of perinatal complications.
Pregnancies delivered (PD) is appropriate for outcomes occurring post-delivery.
Ongoing pregnancies (OP) is essential for outcomes at risk before delivery, like antepartum stillbirth.

Key Insights:

Utilizing appropriate denominators (PD vs. OP) is vital for accurate perinatal complication assessment.
Inconsistent reporting methodologies can lead to misleading clinical and policy recommendations.
Standardizing outcome reporting by gestational age is necessary for reliable data interpretation.

Outlook:

Future research should prioritize standardized definitions and denominators for perinatal outcomes.
Clearer reporting guidelines will enhance the comparability of studies and inform evidence-based practice.
Accurate data is essential for improving maternal and infant health outcomes.