Detection and quantification of calcifications in intravascular ultrasound images by automatic thresholding

An innovative application of automatic thresholding is used for the detection of calcification regions in intravascular ultrasound images. A priori knowledge of the acoustic shadow that usually accompanies calcification regions is used to discriminate these from other bright regions in the image. A method for the calculation of the angle of calcification has also been developed. The proposed algorithms are applied to in-vivo images obtained from left anterior descending coronary arteries during percutaneous transluminal coronary angioplasty (n = 14). The resulting specificity is 72% and the sensitivity 84%. The receiver operating characteristic curve, the area under the curve being equal to 0.91, is plotted to evaluate the algorithm performance.