Related Experiment Video

Updated: Jul 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Introduction to 'A multitargeted approach: clinical advances in the treatment of solid tumours'

D George1, J Verweij

  • 1Division of Urology, Duke University Medical Center, Durham, NC 27705, USA. Daniel.george@duke.edu

Annals of Oncology : Official Journal of the European Society for Medical Oncology
|November 21, 2007
PubMed

Insights

Multitargeted cancer therapies overcome drug resistance by inhibiting multiple pathways simultaneously. This approach shows promise in treating solid tumours, with sunitinib malate as a key example.

Area of Science:

  • Oncology
  • Pharmacology
  • Cancer Biology

Background:

  • Single-target cancer agents face challenges due to drug resistance mediated by compensatory salvage pathways.
  • Multitargeted agents offer a strategy to overcome resistance by simultaneously inhibiting multiple signalling pathways.

Discussion:

  • The symposium focused on clinical advances in treating solid tumours using multitargeted agents.
  • Presentations highlighted recent data on the efficacy of these agents in various cancer types.
  • Sunitinib malate (Sutent) was a key focus, showcasing its role in multitargeted therapy.

Key Insights:

  • Simultaneous inhibition of multiple targets can enhance anti-tumour effects and inhibit tumour vasculature.
  • Emerging clinical data support the effectiveness of multitargeted strategies in solid tumour treatment.
  • Multitargeted agents represent a significant advancement over single-target therapies in managing cancer drug resistance.

Outlook:

  • Further clinical investigation and application of multitargeted agents are anticipated.
  • Sunitinib malate and similar agents are expected to play a growing role in personalized cancer treatment.
  • The development of novel multitargeted therapies holds promise for improving patient outcomes in oncology.

More Related Videos

Screening Ion Channels in Cancer Cells06:19

Screening Ion Channels in Cancer Cells

Published on: June 16, 2023

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...