Related Experiment Videos
A critique and impact analysis of decision modeling assumptions
Jonathan Karnon1, Alan Brennan, Ron Akehurst
1School of Health and Related Research, University of Sheffield, Sheffield, UK. j.karnon@sheffield.ac.uk
Background:
A descriptive analysis of 4 modeling issues (inclusion of incident cases over a model time horizon, appropriate time horizon, parsimonious model structure, and the handling of age-specific subgroups) is presented. A case study model is analyzed to illustrate the quantitative impact of 3 of the issues.
Results:
In the case study model, alternative specifications of the modeling framework are shown to alter the estimated cost-effectiveness by large percentages. The combined effect of including incident cases and reduced follow-up yielded the highest divergence from the reference case results, by between 20% and 40%, depending on the age group. Reference case results of an age-weighted population were almost 14% different from the middle single age cohort.
Discussion:
The identified issues are all generalizable to a wide range of treatment areas and are, or should be, addressed by evaluative guidelines. The authors call for the continued development, dissemination, and application of guidelines for the conduct of economic evaluation in general and model-based economic evaluations in particular.
Related Concept Videos
Decision Making
Automatic decision-making is fast, intuitive, and relies on gut feelings...
Decision Making: P-value Method
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim is also stated. These statements can act as null and alternative hypotheses: a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
Decision Making: Traditional Method
First, a specific claim about the population parameter is decided based on the research question and is stated in a simple form. Further, an opposing statement to this claim is also stated. These statements can act as null and alternative hypotheses, out of which a null hypothesis would be a...
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Methods of Documentation VI: Case Management Model
For example, a patient with a chronic illness...
Modeling in Therapy
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in situations...