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Related Experiment Videos

Sleep disturbances in asthma: theophylline versus enprofylline.

C Janson1, T Gislason, L Laxmyr

  • 1Department of Lung Medicine, Uppsala University.

Upsala Journal of Medical Sciences
|January 1, 1991
PubMed
Summary

Replacing theophylline with enprofylline did not improve sleep quality for asthma patients. This suggests adenosine receptor antagonism may not cause theophylline-related sleep disturbances in asthma.

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Area of Science:

  • Pulmonology
  • Pharmacology
  • Sleep Medicine

Background:

  • Asthma patients on theophylline often report sleep disturbances.
  • Theophylline's mechanism involves adenosine receptor antagonism, a potential cause of sleep issues.

Purpose of the Study:

  • To investigate if enprofylline, an alternative medication, improves sleep quality in theophylline-treated asthma patients.
  • To explore the role of adenosine receptor antagonism in sleep disturbances associated with theophylline therapy.

Main Methods:

  • A double-blind, cross-over study involving 22 asthma patients with reported sleep problems.
  • Patients received either theophylline or an equipotent dose of slow-release enprofylline for three-week periods.
  • Sleep quality was assessed using questionnaires and sleep diaries; lung function was measured by peak expiratory flow (PEF).

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Main Results:

  • No significant differences in subjective sleep quality were found between theophylline and enprofylline treatments.
  • Morning peak expiratory flow (PEF) showed no difference, but evening PEF was slightly higher with theophylline.
  • Enprofylline did not subjectively improve sleep quality compared to theophylline in this patient group.

Conclusions:

  • Switching from theophylline to enprofylline does not enhance sleep quality in asthmatic patients.
  • Adenosine receptor antagonism is unlikely to be the primary cause of sleep disturbances in this theophylline-treated asthma population.