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Updated: Jul 12, 2026
Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte Interactions
Published on: November 9, 2020
Delayed IGF-1 administration rescues oligodendrocyte progenitors from glutamate-induced cell death and
Teresa L Wood1, Vaho Loladze, Stefanie Altieri
1Department of Neurology and Neuroscience, New Jersey Medical School, University of Medicine and Dentistry New Jersey, Newark, NJ 07103, USA. woodte@umdnj.edu <woodte@umdnj.edu>
Abstract:
We previously demonstrated that IGF-1 blocks glutamate-mediated death of late oligodendrocyte progenitors (OPs) by preventing Bax translocation, mitochondrial cytochrome c release and cleavage of caspases 9 and 3. Here, we demonstrate that IGF-1 prevents caspase 3 activation in late OPs when administered up to 16 h following exposure to glutamate. Moreover, late addition of IGF-1 to OPs previously exposed to toxic levels of glutamate promotes oligodendrocyte maturation as measured by myelin basic protein expression. We also demonstrate that intraventricularly administered IGF-1 retains OPs in the perinatal white matter after hypoxia-ischemia when given after insult. These results suggest that delayed administration of IGF-1 will rescue OPs in the immature white matter and promote myelination following hypoxia-ischemia.
