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Related Experiment Video

Updated: Jul 12, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

The fetal inflammatory response syndrome.

Francesca Gotsch¹, Roberto Romero, Juan Pedro Kusanovic

¹Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, Maryland, USA.

Clinical Obstetrics and Gynecology

|September 1, 2007

Summary

The fetal inflammatory response syndrome (FIRS) involves systemic inflammation and elevated interleukin-6 in fetuses, increasing risks for preterm birth complications and long-term health issues like brain injury.

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Last Updated: Jul 12, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

Perinatal Medicine
Fetal Physiology
Immunology

Background:

Fetal inflammatory response syndrome (FIRS) is a significant condition in neonatology.
Characterized by systemic inflammation and elevated fetal plasma interleukin-6.
Associated with preterm labor, ruptured membranes, and fetal viral infections like cytomegalovirus.

Purpose of the Study:

To review the fetal systemic inflammatory response as a mechanism of disease.
To describe potential interventions for controlling exaggerated in utero inflammation.
To highlight the impact of FIRS on perinatal outcomes.

Main Methods:

Literature review of studies on FIRS.
Analysis of clinical observations and experimental data.
Synthesis of information on multi-organ involvement in FIRS.

Main Results:

FIRS is a risk factor for short-term perinatal morbidity and mortality.
FIRS contributes to long-term sequelae, including bronchopulmonary dysplasia and brain injury.
Multiorgan involvement observed in hematopoietic, thymus, adrenal, skin, kidney, heart, lung, and brain systems.

Conclusions:

FIRS is a critical mediator of adverse fetal outcomes.
Understanding FIRS mechanisms is key to developing targeted interventions.
Early recognition and management of FIRS are crucial for improving neonatal health.