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Published on: February 26, 2014
Age-dependent effects of neonatal methamphetamine exposure on spatial learning
Charles V Vorhees1, Matthew R Skelton, Michael T Williams
1Division of Neurology, Cincinnati Children's Research Foundation, Cincinnati, Ohio 45229-3039, USA.
Behavioural Pharmacology
|September 1, 2007
Summary
Neonatal methamphetamine (MA) exposure causes lasting spatial learning and memory deficits in rats. These impairments emerge early and persist for at least one year, impacting cognitive function.
Area of Science:
- Neuroscience
- Developmental Toxicology
- Behavioral Pharmacology
Background:
- Neonatal exposure to drugs of abuse can lead to long-term neurodevelopmental consequences.
- Methamphetamine (MA) is a potent psychostimulant with known neurotoxic effects.
Purpose of the Study:
- To investigate the emergence and permanence of spatial learning and memory deficits induced by neonatal MA exposure in rats.
- To determine the long-term effects of early-life MA exposure on cognitive function.
Main Methods:
- Neonatal rats were administered MA or saline on postnatal days 11-20.
- Cognitive function was assessed using the Morris water maze at various ages (postnatal days 30, 40, 180, and 360).
- Testing included acquisition, reversal, and reduced platform phases, with probe trials to assess reference memory.
Main Results:
- MA-treated rats exhibited significant spatial learning and reference memory deficits compared to saline controls.
- These deficits were largely independent of the age at which testing began.
- Impairments persisted from early development (postnatal day 30) up to one year of age.
Conclusions:
- Neonatal MA exposure induces persistent spatial learning and reference memory deficits.
- These cognitive impairments emerge early and are permanent, lasting at least until one year of age.
- Early-life MA exposure poses a significant risk for long-term cognitive dysfunction.
