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Late vitamin K deficiency bleeding: 16 cases reviewed
Hakan Doneray1, Huseyin Tan, Mustafa Buyukavci
1Department of Pediatrics, Ataturk University, Faculty of Medicine, Erzurum, Turkey. hdoneray@hotmail.com
Insights
Late vitamin K deficiency bleeding affects infants between 30-130 days old, often presenting with pallor and intracranial hemorrhage. Increased awareness of vitamin K prophylaxis is crucial for prevention.
Area of Science:
- Pediatrics
- Neonatology
- Hematology
Background:
- Late vitamin K deficiency bleeding (VKDB) is a serious condition in infants.
- Understanding its clinical and demographic features is essential for timely diagnosis and management.
Observation:
- This study analyzed 16 infants aged 30-130 days with late VKDB.
- Most infants had uneventful delivery and no family history of bleeding disorders.
- Parental awareness of vitamin K prophylaxis at birth was often lacking.
Findings:
- Pallor was the most common presenting symptom (62.5%).
- Intracranial hemorrhage occurred in 37.5% of cases, leading to death in 12.5%.
- No underlying illnesses explained the abnormal coagulation profiles.
Implications:
- Late VKDB remains a significant pediatric health concern.
- Healthcare providers and parents require education on the critical importance of vitamin K prophylaxis.
- Universal vitamin K administration at birth can prevent this potentially fatal condition.
Abstract:
In this study, clinical and demographic features of 16 cases with late vitamin K deficiency bleeding are presented. Ages of infants were between 30 and 130 days. Their delivery histories were uneventful, and family histories for bleeding disorders were negative. All parents except one were unaware of whether their children received vitamin K at birth or not. All cases did not have any underlying illness to explain the abnormal coagulation profile. The common presenting finding was pallor (62.5%). Intracranial haemorrhage was the most common bleeding site (37.5%), and two patients (12.5%) died because of it. Late vitamin K deficiency bleeding is still an important handicap in infants. Parents and healthcare providers should be informed about the importance of vitamin K prophylaxis to prevent vitamin K deficiency in infants.
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