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Related Experiment Videos

Handedness and functional MRI-activation patterns in sentence processing.

Silke Jörgens1, Raimund Kleiser, Peter Indefrey

  • 1Department of Neurology, Heinrich-Heine-University Düsseldorf, Germany. joergesi@uni-duesseldorf.de

Neuroreport
|September 1, 2007
PubMed
Summary
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Left-handed individuals exhibit stronger bilateral brain activation during sentence processing, particularly in frontal and cerebellar regions. This suggests a more distributed language network in left-handers compared to right-handers.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Psycholinguistics

Background:

  • Cerebral lateralization for language is typically left-dominant in right-handed individuals.
  • Understanding hemispheric language processing in left-handed individuals is crucial for a complete model of brain function.
  • Previous research indicates variations in language network organization among left-handers.

Purpose of the Study:

  • To investigate differences in cerebral activation patterns during sentence processing between right-handed and left-handed participants.
  • To explore the extent of bilateral language network involvement in left-handed individuals.
  • To determine if handedness influences the lateralization of specific brain regions involved in language.

Main Methods:

  • Functional Magnetic Resonance Imaging (fMRI) was employed to measure brain activity.

Related Experiment Videos

  • Participants (12 right-handed, 12 left-handed) completed a sentence-processing task.
  • Analysis focused on activation in speech-related areas, including frontal and parietal cortices, and the cerebellum.

    • Main Results:

    • Both groups showed activation in typical left-hemisphere speech areas (BA 44, BA9, BA 40).
    • Left-handed participants displayed stronger bilateral activation in these areas and increased activation in right-frontal (BA 47, BA 6) and left cerebellar regions.
    • Laterality indices for the inferior-frontal cortex were less asymmetric in left-handers, irrespective of their degree of handedness.

    Conclusions:

    • Sentence processing engages a more bilateral language network in left-handed individuals compared to right-handed individuals.
    • These findings highlight variations in brain organization for language based on handedness.
    • The study contributes to understanding the neurobiological underpinnings of language lateralization.