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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
12:18

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Published on: April 23, 2015

The mouse ascending: perspectives for human-disease models.

Nadia Rosenthal1, Steve Brown

  • 1Mouse Biology Unit, EMBL Monterotondo Outstation, via Ramarini 32, 00016, Monterotondo, Rome, Italy. rsn@embl-monterotondo.it

Nature Cell Biology
|September 1, 2007
PubMed
Summary

Laboratory mice are essential for studying human diseases due to shared genetics. Advanced genome manipulation tools and international initiatives enhance their utility for creating accurate human disease models.

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Area of Science:

  • Genetics and Genomics
  • Comparative Biology
  • Disease Modeling

Background:

  • The laboratory mouse is a premier model organism for human disease research, sharing 99% of its genes with humans.
  • A long history of genetic experimentation has been significantly enhanced by novel genome manipulation technologies.

Purpose of the Study:

  • To highlight the indispensable role of the mouse in biomedical research.
  • To underscore the impact of advanced genetic tools and international consortia in disease modeling.

Main Methods:

  • Utilizing established mouse genetic experimentation.
  • Leveraging new genome manipulation tools.
  • Participating in international initiatives for gene function analysis (mutagenesis, molecular analysis, phenotyping).

Main Results:

  • Demonstrated utility of mice in translating human genomic information.
  • Development of increasingly accurate models of human disease.
  • Advancement of understanding mouse gene function.

Conclusions:

  • The mouse remains a critical model organism for human health research.
  • Ongoing international efforts are crucial for functional genomics and disease modeling.
  • Technological advancements continue to expand the mouse's utility in biomedical science.