Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Patching the gaps in Hedgehog signalling.

Rajat Rohatgi1, Matthew P Scott

  • 1Department of Developmental Biology, Howard Hughes Medical Institute, Clark Center West W252, 318 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305-5439, USA.

Nature Cell Biology
|September 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.

Nature genetics·2026
Same author

Regulation of EIF5A and hypusination by p53 determines colorectal cancer cell fitness.

Cancer letters·2026
Same author

Design principles of a membrane-spanning ubiquitin ligase.

Molecular cell·2026
Same author

Multiple modes of cholesterol translocation in the human Smoothened receptor.

eLife·2026
Same author

Expanding roles of N-glycosylation in the endoplasmic reticulum.

Trends in cell biology·2026
Same author

Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.

bioRxiv : the preprint server for biology·2025
Same journal

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.

Nature cell biology·2026
Same journal

Primate neurons with special signalling logic.

Nature cell biology·2026
Same journal

Cell surface liposome binding (CLiB) allows lipid-binding probe engineering via high-throughput screening.

Nature cell biology·2026
Same journal

Mapping the human female reproductive tract.

Nature cell biology·2026
Same journal

Learning from stem cell-based embryo models.

Nature cell biology·2026
Same journal

Why the temporal dimension matters in cellular signalling.

Nature cell biology·2026
See all related articles

The Hedgehog (Hh) pathway is crucial for development and stem cells. Understanding how Patched inhibits Smoothened offers new cancer treatment strategies.

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The Hedgehog (Hh) signaling pathway is vital for animal development and stem-cell function.
  • Dysregulation of Hh signaling is implicated in human birth defects and cancers.
  • Key components include the tumor suppressor Patched (Ptc) and proto-oncogene Smoothened (Smo).

Purpose of the Study:

  • To elucidate the biochemical mechanisms by which Patched inhibits Smoothened.
  • To explore the role of sterol metabolites and primary cilia in Hh pathway regulation.
  • To identify novel therapeutic targets for Hh-related cancers.

Main Methods:

  • Investigating the interaction between Patched and Smoothened proteins.
  • Analyzing the influence of sterol metabolites on Hh pathway activity.

Related Experiment Videos

  • Studying protein trafficking dynamics within the primary cilium.

    • Main Results:

    • Recent findings link Hh signaling to sterol metabolites.
    • Protein-trafficking events at the primary cilium are crucial for Hh pathway regulation.
    • The interaction between Ptc and Smo is a critical regulatory step.

    Conclusions:

    • Understanding the Ptc-Smo interaction is key to deciphering Hh pathway regulation.
    • Sterol metabolites and primary cilia are promising targets for therapeutic intervention.
    • New avenues for cancer treatment can be developed by targeting the Hh pathway.