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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Does prematurity affect thrombocytopoiesis?
Alicja Wasiluk1, Maria Mantur, Izabela Kemona-Chetnik
1Department of Neonatology, Medical University, Bialystok, Poland. awasiluk@amb.edu.pl
Abstract:
Data concerning thrombocytopoiesis in newborns are poorly recognized. Platelets have a crucial role in hemostatic physiology, which is deficient in newborns, especially in preterm newborns. A total of 51 preterm newborns (PTN), 25 girls and 26 boys, were recruited for the study. The control group consisted of 25 female and 30 male healthy term newborns (HTN). Plasma thrombopoietin (TPO) was measured using Quantikine human TPO system. Reticulated platelets (PLRET) was estimated by means of Retic-Count Kit. Platelet count (PLT) was determined using Advia(TU) 120 Hematology System. TPO was evidently higher in PTN (110.9 pg/ml) than in HTN (71.5 pg/ml), (p < 0.001). The percentage of reticulated platelets (PLRET) was also twice as high in PTN (3.49%) in comparison to HTN (1.7%), (p < 0.001). The PLT count was lower in PTN (246.7 x 10(3) microL) than in HTN (287.2 x 10(3) microL), (p < 0.01). Increased TPO levels and the percentage of PLRET indicate that thrombocytopoiesis is more active in prematurity. Our finding may be useful in therapeutic strategies.
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