Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Changes in HbA<sub>1c</sub> and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture.

Obesity science & practice·2017

Same author

Central nervous system lipocalin-type prostaglandin D2-synthase is correlated with orexigenic neuropeptides, visceral adiposity and markers of the hypothalamic-pituitary-adrenal axis in obese humans.

Journal of neuroendocrinology·2011

Same author

Adiponectin in relation to insulin sensitivity and insulin secretion in the development of type 2 diabetes: a prospective study in 64-year-old women.

Journal of internal medicine·2011

Same author

The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old Swedish men.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2010

Same author

Association between impaired glucose tolerance and carotid atherosclerosis: a study in 64-year-old women and a meta-analysis.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2008

Same author

Adiponectin: saving the starved and the overfed.

Medical hypotheses·2007

Search research articles

Related Experiment Video

Updated: Jul 12, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

Published on: December 5, 2025

Adiponectin, obesity and atherosclerosis.

C J Behre¹

¹Wallenberg Laboratory for Cardiovascular Research, Institute of Internal Medicine, Sahlgrenska University Hospital, Göteborg University, Gothenburg, Sweden. behre@wlab.gu.se

Scandinavian Journal of Clinical and Laboratory Investigation

|September 1, 2007

Summary

Adiponectin, a protein from fat cells, has anti-inflammatory and anti-diabetic effects. Low adiponectin levels predict type 2 diabetes and cardiovascular disease risk.

Area of Science:

Endocrinology
Metabolic research
Immunology

Background:

Adiponectin is a circulating protein discovered in the 1990s.
Secreted by mature adipocytes, it plays a role in metabolic regulation.
Low adiponectin levels are linked to increased risk of type 2 diabetes and cardiovascular disease.

Purpose of the Study:

To review the role of adiponectin in obesity.
To discuss the relationship between adiponectin, inflammation, and insulin resistance.
To explore the connection between adiponectin and atherosclerosis.

Main Methods:

Literature review of studies on adiponectin.
Analysis of research linking adiponectin to metabolic and inflammatory conditions.
Synthesis of current understanding of adiponectin's function.

More Related Videos

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Related Experiment Videos

Last Updated: Jul 12, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

Published on: December 5, 2025

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Isolation and Culturing of Primary Murine Adipocytes from Lean and Obese Mice

Published on: January 24, 2025

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

Main Results:

Adiponectin exhibits significant anti-inflammatory and anti-diabetic properties.
Obesity is often associated with lower circulating adiponectin levels.
Reduced adiponectin is a predictor for developing type 2 diabetes and cardiovascular disease.

Conclusions:

Adiponectin is a key player in metabolic health and inflammation.
Understanding adiponectin's role is crucial for managing obesity, insulin resistance, and cardiovascular risks.
Further research into adiponectin may offer therapeutic targets for related diseases.