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A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
TNF receptor I polymorphism is associated with persistent palindromic rheumatism
1Division of Allergy, Immunology, and Rheumatology, Kaohsiung Veterans General Hospital, Taiwan. lylu@isca.vghks.gov.tw
Scandinavian Journal of Rheumatology
|September 1, 2007
Summary
Single nucleotide polymorphisms (SNPs) in the Tumor Necrosis Factor Receptor Superfamily Member 1A (TNFRSF1A) gene are associated with persistent palindromic rheumatism (PR). This suggests TNF Receptor I (TNFRI) plays a role in PR development.
Area of Science:
- Genetics and Immunology
- Rheumatology
Background:
- Persistent palindromic rheumatism (PR) is a chronic inflammatory condition.
- The role of specific genetic polymorphisms in PR susceptibility is not fully understood.
Purpose of the Study:
- To investigate the association between single nucleotide polymorphisms (SNPs) in key inflammatory cytokine genes and persistent PR.
- Specifically examining polymorphisms in tumor necrosis factor-alpha (TNFalpha), TNF receptor superfamily member 1A (TNFRSF1A/TNFRI), TNFRSF1B (TNFRII), and interleukin-1beta (IL-1beta).
Main Methods:
- Genotyping of 56 PR patients and 100 healthy controls.
- Real-time polymerase chain reaction (RT-PCR) was used to analyze specific SNPs in TNFalpha, TNFRSF1A, TNFRSF1B, and IL-1beta genes.
Main Results:
- A significant association was found between the TNFRSF1A +36G allele and the +36AG genotype and persistent PR.
- The frequency of TNFRSF1B +676T/+1663A was higher in PR patients but did not reach statistical significance after correction.
- No significant correlations were observed for TNFalpha or IL-1beta SNPs.
Conclusions:
- SNPs within the TNFRSF1A gene are associated with persistent PR.
- These findings suggest that TNF Receptor I (TNFRI) is implicated in the aetiopathogenesis of persistent palindromic rheumatism.
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