Related Experiment Video
Updated: Jul 12, 2026

Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis
Published on: October 13, 2016
External ophthalmoplegia as the presenting feature of systemic amyloidosis
Kim Son Lett1, Ameet Shah, Irene Gottlob
1Department of Ophthalmology, University Hospitals of Leicester, Leicester, UK.
Introduction:
Amyloidosis is a multi-system disease characterised by the intracellular deposition of beta-pleated sheets of amyloid. It can involve the eye, orbit and ocular adnexae.
Method:
We describe a case of a 58-year-old woman presenting to the eye department with external ophthalmoplegia, including the findings of various investigations. The spectrum of ocular amyloidosis is discussed.
Conclusion:
Amyloidosis may be the underlying diagnosis in some cases of external ophthalmoplegia with findings atypical to other systemic disease.
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining, normally used to...
Glaucoma: Overview
Accessory Structures of the Eye
Myasthenia Gravis ll: Pathophysiology
Multiple Sclerosis l: Introduction
