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Updated: Jul 12, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

Chorioamnionitis and brain damage in the preterm newborn.

Gustavo Rocha¹, Elisa Proença, Conceição Quintas

¹Pediatric Department, Division of Neonatology, Hospital de São João, University Hospital, Porto, Portugal. gusrocha@oninet.pt

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

|September 1, 2007

Summary

Histological chorioamnionitis is linked to cystic periventricular leukomalacia in preterm newborns. However, this study did not confirm a link between chorioamnionitis and intraventricular hemorrhage in this vulnerable population.

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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

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Published on: June 24, 2020

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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

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Published on: November 20, 2015

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Area of Science:

Neonatal Medicine
Perinatal Pathology
Neuroscience

Background:

Histological chorioamnionitis is an inflammatory condition of the placenta.
It is associated with adverse perinatal outcomes in preterm infants.
Brain damage, including intraventricular hemorrhage and cystic periventricular leukomalacia, are significant concerns in preterm neonates.

Purpose of the Study:

To investigate the association between histological chorioamnionitis and specific types of brain injury in preterm neonates.
To determine if placental inflammation correlates with intraventricular hemorrhage (IVH) and cystic periventricular leukomalacia (PVL).

Main Methods:

A retrospective study was conducted on 452 neonates born before 34 weeks gestational age.
Data were collected from three tertiary medical centers in Portugal between 2001 and 2002.
The presence of histological chorioamnionitis in maternal placentas was analyzed in relation to neonatal brain injury.

Main Results:

Histological chorioamnionitis was present in 125 mothers' placentas.
A significant association was found between chorioamnionitis and cystic periventricular leukomalacia (OR 3.02).
The association between chorioamnionitis and severe intraventricular hemorrhage (grades III-IV) was not statistically confirmed after adjusting for confounders (OR 0.94).

Conclusions:

This study confirms a significant association between histological chorioamnionitis and the development of cystic periventricular leukomalacia in preterm infants.
The study did not find a confirmed association between histological chorioamnionitis and intraventricular hemorrhage in this cohort.
Further research may be needed to elucidate the complex relationship between placental inflammation and neonatal brain injury.