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19:57
An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Is it time to rethink the expanded-access programs for HIV infection?
Valerianna Amorosa1, Pablo Tebas
1University of Pennsylvania, Philadelphia, PA 19104, USA. valerianna.amorosa@uphs.upenn.edu
The Journal of Infectious Diseases
|September 1, 2007
Summary
Expanded-access programs (EAPs) provide early access to antiretroviral therapy for patients lacking other options. This review proposes an updated EAP model to maximize patient benefit and gather knowledge for multidrug-resistant HIV treatment.
Area of Science:
- Infectious Diseases
- Clinical Pharmacology
Background:
- Expanded-access programs (EAPs) historically provided pre-approval access to antiretroviral therapy (ART).
- Significant advancements in ART over two decades necessitate a re-evaluation of EAP models.
- Current EAPs may not fully leverage the potential for knowledge generation in complex HIV cases.
Purpose of the Study:
- To review the historical evolution of antiretroviral EAPs.
- To propose an updated EAP model for improved patient outcomes.
- To enhance knowledge generation for treating multidrug-resistant HIV.
Main Methods:
- Historical review of antiretroviral EAP literature and guidelines.
- Analysis of treatment paradigms in human immunodeficiency virus (HIV) over the past 20 years.
- Development of a conceptual framework for an updated EAP model.
Main Results:
- Antiretroviral EAPs have evolved alongside therapeutic advancements.
- Existing EAP structures may require modification to optimize data collection and patient care.
- A revised model can better address the needs of patients with limited treatment options.
Conclusions:
- A historical perspective highlights the changing role of EAPs in HIV treatment.
- An updated EAP model is proposed to maximize patient benefit and scientific knowledge.
- This framework aims to guide treatment decisions for individuals with multidrug-resistant HIV infections.
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