Detection of human bocavirus in children hospitalized because of acute gastroenteritis

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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR
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Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Jae In Lee1, Ju-Young Chung, Tae Hee Han

  • 1Department of Virus Research, Seoul Health-Environmental Research Center, Sanggyepaik Hospital, Seoul, Korea.

The Journal of Infectious Diseases
|September 1, 2007
PubMed

Insights

Human bocavirus (hBoV) was investigated in children with gastroenteritis. This study found hBoV in 0.8% of cases, suggesting a minor role in pediatric gastroenteritis.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Gastroenterology

Background:

  • Gastrointestinal symptoms are frequently observed in children.
  • Human bocavirus (hBoV) has been hypothesized to contribute to gastroenteritis.

Purpose of the Study:

  • To determine the prevalence of hBoV in children hospitalized with gastroenteritis.
  • To identify other viral etiologic agents responsible for gastroenteritis in this cohort.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) and reverse-transcriptase polymerase chain reaction (RT-PCR) were utilized.
  • Viral agents were detected in a cohort of 962 children hospitalized with gastroenteritis.

Main Results:

  • A viral agent was identified in 44.4% of the children.
  • Rotavirus (25.7%), norovirus (13.7%), adenovirus (3.0%), and astrovirus (1.1%) were the most common viral pathogens.
  • Human bocavirus (hBoV) was detected in 0.8% of the study population.

Conclusions:

  • Human bocavirus (hBoV) appears to play a minor role in pediatric gastroenteritis.
  • Other common viruses are the primary causes of gastroenteritis in hospitalized children.

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