Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estimation and confidence regions for multi-dimensional effective dose.

Jialiang Li1, Erik V Nordheim, Chunming Zhang

  • 1Department of Statistics and Applied Probability, National University of Singapore, 117546, Singapore. stalj@nus.edu.sg

Biometrical Journal. Biometrische Zeitschrift
|September 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient semi-supervised estimation of optimal individualized treatment regimes with survival outcome.

Statistical methods in medical research·2026
Same author

The neutrophil-to-lymphocyte ratio and incident chronic kidney disease in a community-based cohort: a prospective study.

Scientific reports·2026
Same author

MXene/RGO/Si Schottky Junction for a High-Performance Self-Powered Broadband Photodetector.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Hippocampal GFAP in aging: Associations with AD and LATE-NC pathologies and cognitive decline in older adults.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Preoperative dermatomal somatosensory evoked potentials in risk prediction of early postoperative neurological deterioration after thoracic spine surgery: a retrospective cohort study.

Journal of orthopaedic surgery and research·2026
Same author

Synergistic Design of ZnCo-MnO@NPC Cathode and ZIF-8@Zn Anode for High-Performance Aqueous Zinc-Ion Batteries.

Molecules (Basel, Switzerland)·2026
Same journal

Comparison of Different Methods for the Meta-Analysis of Diagnostic Test Accuracy Studies-A Simulation Study.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

When to Adjust for Multiple Testing: A Unifying Guiding Principle.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Ensuring Quality in Preclinical Research: The Importance of Being Human.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Addressing Cluster-Level Treatment Effect Heterogeneity in Sample Size Determination for Hierarchical 2 × 2 Factorial Designs.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

A Multiple Imputation Approach to Distinguish Curative From Life-Prolonging Effects in the Presence of Missing Covariates.

Biometrical journal. Biometrische Zeitschrift·2026
Same journal

Tests for Categorical Data Beyond Pearson: A Distance Covariance and Energy Distance Approach.

Biometrical journal. Biometrische Zeitschrift·2026
See all related articles

This study introduces a new framework for estimating multi-dimensional effective dose for binary outcomes, addressing challenges in finding confidence regions for multiple predictor variables. The method provides a practical approach for analyzing complex biological data, such as decompression sickness.

Area of Science:

  • Biostatistics
  • Regression Analysis
  • Toxicology

Background:

  • Confidence region estimation for multiple predictor variables remains a challenge.
  • Existing methods are inadequate for determining multi-dimensional effective dose for binary outcomes.

Purpose of the Study:

  • To develop a conceptual framework for estimating the multi-dimensional effective dose for binary outcomes.
  • To provide a practical method for calculating confidence regions for predictor variables in logistic regression models.

Main Methods:

  • Developed a framework for estimating k-dimensional effective dose by conditioning on k-1 components.
  • Compared various confidence region calculation approaches via simulation.
  • Applied the procedure to analyze decompression sickness data.

Related Experiment Videos

Main Results:

  • The proposed conceptual framework effectively estimates multi-dimensional effective dose.
  • Simulation study validated the practical utility of the confidence region calculation methods.
  • The procedure demonstrated practical applicability in real-world data analysis.

Conclusions:

  • The study offers a practical and statistically sound approach to determining confidence regions for predictor variables in logistic regression.
  • The developed framework enhances the analysis of binary outcomes in toxicological and biological studies.
  • This method provides a valuable tool for researchers dealing with multi-dimensional dose-response relationships.