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Site-specific protein and peptide immobilization on a biosensor surface by pulsed native chemical ligation

Brett Helms1, Ingrid van Baal, Maarten Merkx

  • 1Laboratory of Macromolecular and Organic Chemistry, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.

Chembiochem : a European Journal of Chemical Biology
|September 1, 2007
PubMed
Abstract

No abstract available in PubMed .

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Ligand Binding Sites02:40

Ligand Binding Sites

Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...

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