Related Experiment Video
Updated: Jul 12, 2026
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
Relationship between obstetric history and Rh(D) alloimmunization severity.
Gustavo Lobato1, Cristina Silveira Soncini
1Fetal Medicine Unit, Department of Obstetrics, Fernandes Figueira Institute, Oswaldo Cruz Foundation, Rui Barbosa Avenue 716, Flamengo, CEP: 22250-020, Rio de Janeiro (RJ), Brazil. lobato@iff.fiocruz.br
Archives of Gynecology and Obstetrics
|September 4, 2007
Summary
Obstetric history, including previous neonatal death or intrauterine fetal transfusion (IUT), helps predict Rh(D) alloimmunization severity. Women with a history of these events require closer fetal monitoring for earlier intervention.
Area of Science:
- Maternal-fetal medicine
- Immunology
- Obstetrics
Background:
- Rh(D) alloimmunization poses risks to fetuses.
- Severity assessment is crucial for timely intervention.
- Gestational age at intrauterine fetal transfusion (IUT) indicates severity.
Purpose of the Study:
- To evaluate the relationship between obstetric history and Rh(D) alloimmunization severity.
- To use gestational age at first IUT as a severity indicator.
- To identify obstetric factors predicting severity.
Main Methods:
- Retrospective analysis of Rh(D) alloimmunized pregnancies undergoing IUT (1996-2006).
- Gestational age at first IUT modeled as a linear outcome.
- Association analysis between obstetric history, anti-Rh(D) titers, and gestational age at IUT.
Main Results:
- 82 fetuses underwent IUT with 92.7% survival.
- Group 1 (no prior adverse events) had later IUT (median 32.5 weeks) vs. Group 2 (prior events, median 27 weeks).
- Previous neonatal death, IUT, and exchange transfusion independently correlated with earlier IUT.
Conclusions:
- Obstetric history is a valuable tool for predicting Rh(D) alloimmunization severity.
- Women with prior neonatal death, exchange transfusion, or IUT need closer fetal surveillance.
- Earlier IUT may be necessary for these high-risk pregnancies due to increased hemolysis risk.
Related Concept Videos
01:19Rh Blood Group
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:23Rheumatic Heart Disease I: Introduction
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
02:45Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:10Blood Typing
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
01:20Rheumatic Heart Disease IV: Nursing Management
AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...