The possible role of hyperhomocysteinemia on IVF outcome
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Arianna Pacchiarotti1, Mohamed A Mohamed, Giulietta Micara
1Obstetric and Gynecology, Policlinico Umberto, La Sapienza University of Rome, Viale Regina Elena, Rome, Italy. arypac@aliceposta.it
Purpose:
To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF.
Method:
Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level.
Results:
Pregnancy rate, implantation rate and abortion rate varied significantly (p
Conclusion:
The results suggest that hyperhomocysteinemia could affect IVF outcome.
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