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Updated: Jul 12, 2026
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Bioactive ent-clerodane diterpenoids from Scutellaria barbata
Sheng-Jun Dai1, Jing-Yong Sun, Yan Ren
1School of Pharmaceutical Science, Yantai University, Yantai, People's Republic of China. daishengjun_9@hotmail.com
Abstract:
Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures were elucidated by chemical methods and spectral analyses. in vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.1-7.2 microM.