Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 12, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

Bioactive ent-clerodane diterpenoids from Scutellaria barbata.

Sheng-Jun Dai1, Jing-Yong Sun, Yan Ren

  • 1School of Pharmaceutical Science, Yantai University, Yantai, People's Republic of China. daishengjun_9@hotmail.com

Planta Medica
|September 4, 2007
PubMed
Summary

Four new compounds from Scutellaria barbata D. Don. demonstrated significant cytotoxic activity against human cancer cell lines. These findings highlight potential new treatments for nasopharyngeal, oral, and colorectal carcinomas.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new indole alkaloid with anti-inflammatory from the branches of <i>Nauclea officinalis</i>.

Natural product research·2018
Same author

Reinforced collagen with oxidized microcrystalline cellulose shows improved hemostatic effects.

Carbohydrate polymers·2017
Same author

[Effect of nucleolin on cardiac cell apoptosis in Type 2 diabetic cardiomyopathy mice].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences·2017
Same author

MALAT1 promotes osteosarcoma development by regulation of HMGB1 via miR-142-3p and miR-129-5p.

Cell cycle (Georgetown, Tex.)·2017
Same author

Patient reporting of undesirable events: a pilot study in China.

International journal for quality in health care : journal of the International Society for Quality in Health Care·2017
Same author

Unitary ototoxic gentamicin exposure may not disrupt the function of cochlear outer hair cells in mice.

Acta oto-laryngologica·2017

Area of Science:

  • Natural Products Chemistry
  • Pharmacology
  • Medicinal Chemistry

Background:

  • Scutellaria barbata D. Don. is a traditional medicinal herb.
  • Diterpenoids are a class of natural products with diverse biological activities.

Purpose of the Study:

  • To isolate and characterize new compounds from Scutellaria barbata D. Don.
  • To evaluate the cytotoxic potential of these new compounds against human cancer cell lines.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation via spectroscopic analyses (NMR, MS).
  • In vitro cytotoxic activity assessment using MTT assay.

Main Results:

  • Four new ENT-clerodane diterpenoids were successfully isolated and identified.

Related Experiment Videos

Last Updated: Jul 12, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
07:59

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

Published on: October 4, 2019

  • The isolated compounds exhibited significant in vitro cytotoxic effects against HONE-1, KB, and HT29 cancer cell lines.
  • IC50 values ranged from 3.1 to 7.2 microM, indicating potent activity.

    • Conclusions:

    • The new diterpenoids from Scutellaria barbata possess promising cytotoxic properties.
    • These compounds represent potential leads for the development of novel anticancer therapeutics.
    • Further investigation into their mechanism of action and in vivo efficacy is warranted.