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Updated: Jul 12, 2026

Quantification of Coenzyme A in Cells and Tissues
Published on: September 27, 2019
Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity
Long Wu1, Jia Zeng, Guisheng Deng
1Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong SAR, PRC.
Abstract:
Selective inactivation of cytosolic thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity was studied, which provides an example for rationally developing mechanism-based inhibitors based on a side activity of the enzyme, and may become a supplemental method for better treatment of cardiovascular disease and cancer.
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