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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Related Experiment Video

Updated: Jul 12, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Autism: the quest for the genes.

Nuala H Sykes¹, Janine A Lamb

¹Wellcome Trust Centre for Human Genetics, University of Oxford, UK.

Expert Reviews in Molecular Medicine

|September 4, 2007

Summary

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder with a strong genetic component. Despite advances, identifying specific genetic causes for most autism cases remains challenging.

Area of Science:

Neurogenetics
Developmental Neuroscience
Psychiatric Genetics

Background:

Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder with high heritability.
Previous genetic studies have identified chromosomal regions but failed to pinpoint specific genes.
Prevalence of ASD is higher than previously estimated.

Purpose of the Study:

To review the current state of research into the genetic origins of autism spectrum disorder.
To discuss emerging methodologies and potential future directions in autism genetics research.

Main Methods:

Review of recent advances in genomics, epigenetics, and bioinformatic resources.
Discussion of the utility of endophenotypes in dissecting autism's genetic complexity.

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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

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Analysis of findings from whole-genome scans and association studies.

Main Results:

Genetic variants underlying idiopathic autism remain largely elusive.
New insights into structural genetic variation and epigenetics offer potential etiological mechanisms.
Technological and resource advancements are improving study efficiency and cost-effectiveness.

Conclusions:

Despite challenges, the field of autism genetics is advancing rapidly.
Future research leveraging new technologies and approaches holds promise for uncovering genetic underpinnings of autism.
Continued investigation into genetic and epigenetic factors is crucial for understanding autism aetiology.