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Diastolic dysfunction after an acute myocardial infarction in patients with antecedent hypertension

Niels Holmark Andersen1, Finn Michael Karlsen, Jens Christian Gerdes

  • 1Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark. holmark@ki.au.dk

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|September 4, 2007
PubMed

Insights

Patients with hypertension show impaired diastolic function recovery after myocardial infarction. Despite similar systolic function, their diastolic function did not improve as much as in non-hypertensive individuals.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Hypertension Research

Background:

  • Hypertension is a significant risk factor for cardiovascular disease.
  • Acute myocardial infarction (AMI) affects cardiac function.
  • The impact of antecedent hypertension on post-AMI cardiac recovery requires further investigation.

Purpose of the Study:

  • To evaluate changes in left ventricular systolic and diastolic function.
  • To compare recovery patterns in patients with and without antecedent hypertension after AMI.

Main Methods:

  • A cohort of 38 hypertensive patients with AMI was compared to age-matched controls.
  • Left ventricular volumes, ejection fraction, systolic velocities, and strain were assessed.
  • Diastolic function was evaluated using mitral inflow and mitral ring tissue velocities.

Main Results:

  • Hypertensive patients showed no significant improvement in E/E' or E'/A' ratios.
  • Control subjects demonstrated significant improvements in E/E' and E'/A' ratios.
  • These diastolic function differences persisted despite comparable changes in ejection fraction, volumes, and systolic strain.

Conclusions:

  • Antecedent hypertension is associated with incomplete recovery of diastolic function post-AMI.
  • Diastolic dysfunction recovery is impaired in hypertensive patients compared to controls.
  • Left ventricular volumes and ejection fraction recovery were similar between groups.
Abstract

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