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Isolation and Physiological Analysis of Mouse Cardiomyocytes
Published on: September 7, 2014
Hormones and postpartum cardiomyopathy
Carmen Clapp1, Stéphanie Thebault, Gonzalo Martínez de la Escalera
1Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Campus UNAM-Juriquilla, Querétaro, Qro, México. clapp@servidor.unam.mx
Prolactin, a hormone fundamental for lactation, was recently shown to mediate postpartum cardiomyopathy, a life-threatening disease in late-term and lactating mothers. The detrimental effect of prolactin results from myocardial upregulation of cathepsin-D, which in turn cleaves prolactin to a 16 kDa fragment (vasoinhibin) with anti-angiogenic and pro-apoptotic properties that impair developing cardiac vasculature.
Prolactin, a hormone fundamental for lactation, was recently shown to mediate postpartum cardiomyopathy, a life-threatening disease in late-term and lactating mothers. The detrimental effect of prolactin results from myocardial upregulation of cathepsin-D, which in turn cleaves prolactin to a 16 kDa fragment (vasoinhibin) with anti-angiogenic and pro-apoptotic properties that impair developing cardiac vasculature.
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