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Updated: Jul 12, 2026

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
Published on: June 20, 2015
Evaluation of patient age as a risk factor for intraocular pressure elevation after intravitreal triamcinolone
Dhananjay Shukla1, Nagasubramaniam Vidhya, Noela M Prasad
1Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India. daksh66@gmail.com
Purpose:
To evaluate the effect of patient age on intraocular pressure (IOP) response after intravitreal injection of triamcinolone acetonide (IVTA).
Design:
Interventional case series.
Methods:
A total of 164 outpatients (164 eyes) aged 21 to 80 years (mean, 56.8 years), presenting with exudative age-related maculopathy (51) or macular edema of various etiologies (113), received IVTA (4 mg/0.1 ml). The primary outcome measure was IOP elevation >21 mm Hg. Patients were re-evaluated at one week, and one, three, and six months.
Results:
The mean baseline IOP was 15.07 mm Hg; the mean rise was 6.6 mm Hg. IOP >21 mm Hg was observed in 42 (25.6%) patients. In the age group =45 years, IOP rise occurred in 45% (14/31) patients, compared with 21% (28/133) of older patients (P = .006). The groups were similar in baseline IOP, IOP rise, mean time-lag to maximum IOP, and response to treatment.
Conclusions:
IVTA caused more frequent IOP elevation in younger patients; other aspects of IOP response and its treatment were similar to older patients.
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