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Cell Migration01:09

Cell Migration

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Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
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Cell Migration01:19

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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Switching of BJT01:22

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Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Related Experiment Video

Updated: Feb 9, 2026

In vitro Cell Migration and Invasion Assays
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Tensins: a new switch in cell migration.

Ghassan Mouneimne1, Joan S Brugge

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. joan_brugge@hms.harvard.edu

Developmental Cell
|September 4, 2007
PubMed
Summary

Epidermal Growth Factor (EGF) controls cell movement by altering tensin proteins. This switch weakens beta1 integrin connections to the cell

Area of Science:

  • Cell biology
  • Molecular biology
  • Cancer research

Background:

  • Epidermal Growth Factor (EGF) is crucial for regulating normal epithelial and carcinoma cell migration.
  • The precise molecular mechanisms underlying EGF-induced cell migration remain incompletely understood.

Purpose of the Study:

  • To elucidate the mechanism by which Epidermal Growth Factor (EGF) regulates cell migration.
  • To investigate the role of tensin isoforms in EGF-mediated cell motility.

Main Methods:

  • Analysis of tensin isoform expression.
  • Investigation of beta1 integrin association with the actin cytoskeleton.
  • Study of focal adhesion dynamics.

Main Results:

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  • EGF signaling induces a switch in the expression of two tensin isoforms.
  • This isoform switch leads to a weakened association of beta1 integrin with the actin cytoskeleton.
  • The alterations occur within focal adhesions, impacting cell adhesion and migration.

    • Conclusions:

    • Tensin isoform switching is a key mechanism by which EGF regulates cell migration.
    • Modulation of beta1 integrin-cytoskeleton interactions is critical for EGF-driven cell motility.
    • Findings provide new insights into the molecular basis of cancer cell invasion.