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Updated: Jul 12, 2026

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
Published on: May 4, 2020
Coping with stress: ATF6alpha takes the stage
Ekaterina Bobrovnikova-Marjon1, J Alan Diehl
1The Leonard and Madlyn Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, PA 19104, USA. adiehl@mail.upenn.edu
Abstract:
In this issue of Developmental Cell, two groups, Yamamoto et al. and Wu et al., describe the generation of mice with targeted deletion of the ATF6alpha gene. While ATF6alpha is nonessential for embryonic and postnatal development, deletion has a profound effect on the transcriptional program elicited by endoplasmic reticulum stress, revealing a broader than anticipated role for ATF6 in this signaling network.
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