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Updated: Jul 12, 2026
14:59
Determination of Total Lipid and Lipid Classes in Marine Samples
Published on: December 11, 2021
Allenic and cumulenic lipids
Valery M Dembitsky1, Takashi Maoka
1Department of Medicinal Chemistry and Natural Products, School of Pharmacy, P.O. Box 12065, Hebrew University, Jerusalem 91120, Israel. dvalery@cc.huji.ac.il
Progress in Lipid Research
|September 4, 2007
Summary
Natural and synthetic allenic and cumulenic compounds offer significant potential for drug discovery. This review highlights their diverse structures and potent biological activities, including anticancer and antiviral properties.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Natural Products Chemistry
Background:
- Over 200 natural allenic metabolites and over 2700 synthetic allenic compounds are known.
- Approximately 1300 cumulenic structures have been identified.
- Living organisms produce pharmacologically potent agents with diverse biological activities.
Purpose of the Study:
- To review research on natural and synthetic allenic and cumulenic lipids and related compounds.
- To highlight their biological activities and potential as drug leads.
- To categorize known allenic and cumulenic compounds.
Main Methods:
- Literature review of natural and synthetic allenic and cumulenic compounds.
- Analysis of isolated compounds from various sources.
- Examination of reported biological activities.
Main Results:
- Dozens of compounds with high anticancer, cytotoxic, antibacterial, and antiviral activities have been discovered.
- Allenic and cumulenic compounds can be classified into structural groups such as fatty acids, terpenes, steroids, and carotenoids.
- Marine bromoallenes and peptides represent other significant classes.
Conclusions:
- Natural and synthetic allenic and cumulenic lipids and related compounds are a crucial source for drug discovery.
- These compounds exhibit a wide range of valuable pharmacological properties.
- Further research into these molecules can lead to novel therapeutic agents.
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