Related Experiment Video
Updated: Jul 12, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
[Clinical and pathologic features of melanocytic lesion of the central nervous system]
Ning Zhang1, Zun-Jing Liu, Gang Li
1Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. zhnxyyy@vip.sina.com
Objective:
To investigate the clinical and pathologic features of melanocytic lesion of the central nervous system.
Methods:
We analyzed the clinical features, neuroimages, and operational and neuropathological findings of 2 patients of neurocutaneous melanosis and 4 patients of primary leptomeningeal melanoma.
Results:
All the 6 patients had the common clinical features of intracranial hypertension and epilepsy. Brain CT and MRI showed abnormal signals. More melanin pigment nevi were found on the skin of the 2 patients subjected to neurocutaneous melanosis. The other 4 patients subjected to primary leptomeningeal melanoma had no melanin pigment nevus on the skin, but the brain section displayed positive meningeal melanoma.
Conclusion:
Intracranial hypertension and epilepsy are the main clinical manifestations of melanocytic lesion of the central nervous system, and cutaneous lesion and radiological findings are very important for the diagnosis.
Related Concept Videos
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Multiple Sclerosis l: Introduction
Encephalitis ll: Pathophysiology
Cushing Syndrome II: Pathophysiology
Cryptococcal Meningitis
