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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jul 12, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Difficult asthma: possible association with rhinosinusitis.

D G Peroni1, G L Piacentini, R Ceravolo

  • 1Department of Paediatrics, University of Verona, Italy. peroni.diego@tiscalinet.it

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|December 6, 2007
PubMed
Summary
This summary is machine-generated.

In children with difficult-to-control asthma, rhinosinusitis may be a contributing factor. Treating chronic sinus disease in asthmatic children can improve asthma symptoms and lung function.

Related Experiment Videos

Last Updated: Jul 12, 2026

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Otolaryngology

Background:

  • Difficult-to-control asthma in children necessitates reassessment of diagnosis and risk factors.
  • Epidemiologic data suggest a link between rhinosinusitis and bronchial asthma, though the exact relationship remains debated.
  • Nasal sinus disease may impede asthma control, particularly in severe cases, with CT scans showing more sinus abnormalities.

Purpose of the Study:

  • To explore the association between rhinosinusitis and childhood asthma.
  • To investigate the potential impact of nasal sinus disease on asthma control and exacerbations.
  • To evaluate the therapeutic implications of addressing sinusitis in asthmatic children.

Main Methods:

  • Review of epidemiologic data and clinical observations regarding the co-occurrence of asthma and rhinosinusitis.
  • Analysis of pathogenetic mechanisms, including shared inflammatory mediators and cellular infiltrates (e.g., eosinophils).
  • Evaluation of the effects of antibiotic treatment for chronic sinus disease on asthmatic children's symptoms and lung function.

Main Results:

  • Shared inflammatory pathways and cellular infiltrates (eosinophils) are implicated in both asthma and sinusitis.
  • Antibiotic treatment for chronic sinus disease in asthmatic children has shown improvements in subjective asthma symptoms, lung function, and bronchial hyperreactivity.
  • Patients with severe asthma exhibit more significant paranasal sinus abnormalities on CT scans.

Conclusions:

  • A significant association exists between asthma and sinusitis in children, relevant for diagnosis and treatment.
  • Addressing chronic rhinosinusitis may be a crucial component in managing difficult-to-control childhood asthma.
  • Further research into the pathogenetic links and therapeutic interventions for comorbid asthma and sinusitis is warranted.